Convulsive reaction in a two-year-old child following the accidental ingestion of an overdosage of isoniazid.

S. K., a 26-month-old white male, was adnutted to the hospital because of several generalized convulsions in the preceding hour. The mother had tuberculous pleurisy with effusion in 1938. Tile father had pulmonary tuberculosis with cavitation in 1933 for which pnoumothorax was induced from 1934 to 1939 and a loboctomy performed in 1940. Since 1942 neither parent showed signs of active tuberculosis. The patient was one of twins born 3 weeks prematurely by breech presentation. Birth weight was 1,955 gm. Ho breathed and cried spontaneously. The neonatal period was eventful, development was entirely normal and there were iio serious illnesses or con\. 15 fl5